Synthesis of Prothrombin by liver requires

Synthesis of Prothrombin by the liver requires vitamin K. Vitamin K is primarily located in the hepatic microsomes. Vitamin K-dependent carboxylation (a post-translational modification in Vit K-dependent (VKD) proteins at glutamate amino acids to gamma-carboxyglutamate amino acids) is necessary for the synthesis of blood clotting factor prothrombin.