Which of the following NaCl solution is a hypotonic solution for RBC?

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The 0.5% sodium chloride (NaCl) solution is a hypotonic solution for RBC. The isotonic solution for RBCs is 0.9% NaCl solution. Any solution that is below the concentration of 0.9% NaCl is referred to as the hypotonic solution for RBCs. And any solution that is above the concentration of 0.9% NaCl solution is referred to as the hypertonic solution for RBCs.

The solute concentration of RBCs is similar to the solute concentration of 0.9% NaCl (isotonic solution). When the concentration of NaCl decreased below 0.9% (i.e. 0.5%), the concentration of solute present in that solution is less than the solute concentration of RBCs. Thus, the NaCl solution is referred to as the hypotonic solution.

When RBCs are put in the hypotonic solution, the water molecule (solvent) enters the RBCs. As a result, the RBCs become swell and rupture.