Acetyl-CoA is synthesized from pyruvate in the mitochondria by the enzyme

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Acetyl-CoA is synthesized from pyruvate in the mitochondria by a complex of three enzymes called Pyruvate dehydrogenase complex (PDC). PDC converts pyruvate into acetyl-CoA by a process called pyruvate decarboxylation. Acetyl-CoA is then used in the citric acid cycle to carry out cellular respiration or used as a substrate for histone acetylation.