Inflammatory bowel disease (IBD) involves long-lasting inflammation in the digestive tract and can cause damage to the lining of the bowel with symptoms like blood in the stool, diarrhea, weight loss, belly pain. To find out whether calorie restriction might help to fight inflammation, mice with IBD were fed with low-calories, low-protein, plant-based diet. Gut inflammation and other signs of IBD improved. Average colon length returned to normal size, suggesting tissue regeneration in IBD mice with a low-calorie diet.
Journal: Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD. Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology. Cell Rep. 2019 Mar 5;26(10):2704-2719.e6.